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P. falciparum antimalarial drug resistance genes targeted by the 10-plex amplicon panel.

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posted on 2024-02-01, 18:48 authored by Aurel Holzschuh, Anita Lerch, Bakar S. Fakih, Safia Mohammed Aliy, Mohamed Haji Ali, Mohamed Ali Ali, Daniel J. Bruzzese, Joshua Yukich, Manuel W. Hetzel, Cristian Koepfli

P. falciparum antimalarial drug resistance genes targeted by the 10-plex amplicon panel.

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    PLOS Global Public Health

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    routinely collected rdtsmutations conferring antiincluding minority clonesidentified current challengesmalarial drug resistancelimited sequencing infrastructureendemic areas preventsartemisinin partial resistancediv >< prapid diagnostic testhigh microhaplotype diversityimplementing nanopore sequencingaccelerate malaria controlplasmodium falciparum endemic sites usingend genomic surveillancepolyclonal malaria infectionsnanopore sequencingmalaria controlp falciparum endemic countriesconfer resistancemany malariagenomic datasample diversityrapid genotypingrapid generationgenetic diversitymdr1 dhps dhfr sample inputspolyclonal infectionsmobile laboratorymedian hknown antimalarialsexplore withinelimination effortsdemonstrating evenclose collaborationbioinformatics workflowallows genotyping94 ).60 %)

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