KIF5B P-loop nucleotide binding domain is highly conserved between species.

Marom, Ronit; Zhang, Bo; Washington, Megan E.; Song, I-Wen; Burrage, Lindsay C.; Rossi, Vittoria C.; Berrier, Ava S.; Lindsey, Anika; Lesinski, Jacob; Nonet, Michael L.; Chen, Jian; Baldridge, Dustin; Silverman, Gary A.; Sutton, V. Reid; Rosenfeld, Jill A.; Tran, Alyssa A.; Hicks, M. John; Murdock, David R.; Dai, Hongzheng; Weis, MaryAnn; Jhangiani, Shalini N.; Muzny, Donna M.; Gibbs, Richard A.; Caswell, Richard; Pottinger, Carrie; Cilliers, Deirdre; Stals, Karen; Eyre, David; Krakow, Deborah; Schedl, Tim; Pak, Stephen C.; Lee, Brendan H.

doi:10.1371/journal.pgen.1011005.s009

pgen.1011005.s009.pdf (181.47 kB)

KIF5B P-loop nucleotide binding domain is highly conserved between species.

journal contribution

posted on 2023-11-07, 18:41 authored by Ronit Marom, Bo Zhang, Megan E. Washington, I-Wen Song, Lindsay C. Burrage, Vittoria C. Rossi, Ava S. Berrier, Anika Lindsey, Jacob Lesinski, Michael L. Nonet, Jian Chen, Dustin Baldridge, Gary A. Silverman, V. Reid Sutton, Jill A. Rosenfeld, Alyssa A. Tran, M. John Hicks, David R. Murdock, Hongzheng Dai, MaryAnn Weis, Shalini N. Jhangiani, Donna M. Muzny, Richard A. Gibbs, Richard Caswell, Carrie Pottinger, Deirdre Cilliers, Karen Stals, David Eyre, Deborah Krakow, Tim Schedl, Stephen C. Pak, Brendan H. Lee

Multiple sequence alignment of the N-terminal part of the motor domain of KIF5B and orthologs in other organisms. The highly conserved P-loop region of the ATP-binding domain is highlighted with a green box. The KIF5B p.Thr87Ile variant in proband 1 (red arrowhead) and corresponding C. elegans (worm) unc-116 Thr90 residue (blue arrowhead) are shown.

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