Protein-protein Interactions and Novel Biomarkers of Esophageal Cancer

Esophageal cancer is the eighth most commonly diagnosed cancer and is the sixth leading cause of cancer death worldwide.[1][2] The burden of this malignant tumor is significantly high in less developed regions, where almost 80% of all cases occur. Approximately 70% of cases occur in men, and there is a 2‐ to 5‐fold difference in incidence and mortality rates between the sexes.[2] In addition, esophageal cancer is higher in middle‐aged and elderly populations, and the chance of getting it increases with age.[3] The cancer burden of esophagus incidence and mortality is increasing rapidly worldwide, accompanied by global aging and population growth as well as the prevalence of associated risk factors such as tobacco and alcohol consumption, poor diet, lack of excise, and obesity.[1][4] Esophageal cancer is extremely malignant and prognosis is often poor.