BPJ_Vol_11_No_3_p_1369-1380.pdf (1.65 MB)
Zingiber Officinale Alleviates Maternal and Fetal Hepatorenal Toxicity Induced by Prenatal Cadmium
journal contribution
posted on 2018-09-28, 16:26 authored by Prof. Hesham N. MustafaProf. Hesham N. MustafaThis study was designed to address the protective effects of Zingiber
officinale on the toxic outcomes of prenatal Cadmium administration on
pregnancy outcome. Pregnant female Sprague-Dawley rats were randomly
divided into four groups (eight rats/each), control group received
distilled water, 2nd group treated with 8.8 mg of CdCl2/kg b. wt, 3rd
group treated with 250 mg of Zingiber officinale/kg b. wt, and 4th group
treated with 250 mg of Zingiber officinale/kg b. wt, followed by 8.8 mg
of CdCl2/kg b.wt. Daily body weight of pregnant was recorded from
GD1-GD20, and then pregnant rats were sacrificed at GD20. Samples of
maternal and fetal livers and kidneys were processed for histological
examination. Administration of Cd to pregnant rats showed adverse
effects on pregnant mothers and their fetuses; reduced maternal weight
gain, reduced absolute organ weights, reduced fetal growth parameters
and placental weights together with altered histological appearance of
the maternal and fetal livers and kidneys. While co-administration of
Zingiber officinale showed an improvement of these toxic alterations.
Zingiber officinale through its antioxidant activity could be beneficial
against toxic outcomes of Cd exposure during pregnancy.