<p>In the recent Cerebrum article Equal ≠ the same: Sex differences in the human brain, Larry Cahill offers his perspective on the nature of sex differences in brain and behavior, and what he considers to be a “counter-reaction” to such research by “anti-sex difference” investigators operating from the “deeply ingrained, implicit, false assumption that if men and women are equal, then men and women must be the same.”[1] We welcome this opportunity to correct some of the misapprehensions and mischaracterisations in this account, and present a more nuanced view of the relations among sex, brain and gender.</p>