Water-Tolerant ortho-Acylation of Phenols

Tian, Jie-Sheng; He, Yu; Gao, Zhi-Yuan; Liu, Xu; Dong, Shuang-Feng; Wu, Peng; Loh, Teck-Peng

doi:10.1021/acs.orglett.1c02583.s001

ol1c02583_si_001.pdf (5.62 MB)

Water-Tolerant ortho-Acylation of Phenols

journal contribution

posted on 2021-08-11, 13:06 authored by Jie-Sheng Tian, Yu He, Zhi-Yuan Gao, Xu Liu, Shuang-Feng Dong, Peng Wu, Teck-Peng Loh

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C–C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.