posted on 2023-11-08, 19:40authored byHao-Cong Li, Ke-Yuan Zhao, Yan Tan, Hao-Sen Wang, Wen-Shan Wang, Xiao-Lan Chen, Bing Yu
A visible-light-induced
β-acyl difunctionalization of alkenes
with acyl oxime esters and various nucleophiles was developed to achieve
molecular complexity from readily available raw materials via oxidative
radical-polar crossover. A variety of nucleophiles, including NH-sulfoximines, indoles, indazole, and trimethoxybenzene,
were all effectively applicable to the sustainable reaction system.
The novel synthetic strategy features mild reaction conditions, a
broad substrate scope (39 examples), easy scale-up, and excellent
regioselectivity.