posted on 2023-11-30, 15:00authored byJie Gao, Xian-Chen He, Yan-Ling Liu, Ke-Rong Li, Jian-Ping Guan, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen, Hua Yang
Herein,
a visible-light-induced nickel-catalyzed cross-coupling
of aryl bromide with nitrile has been reported. By utilization of
readily available nitriles as carbonyl precursors, a range of structurally
diverse aryl ketones were facilely constructed. The synthetic simplicity,
mild reaction conditions, and acidic functional group tolerance would
broaden the synthetic utilities of this developed protocol as an expedient
alternative to Grignard/organolithium protocols.