posted on 2023-11-17, 19:41authored byBingran Chen, Qinlin Chen, Yang Liu, Jinxiu Chen, Xi Zhou, Haifeng Wang, Qiongjiao Yan, Wei Wang, Zeyu Cai, Fen-Er Chen
Herein, we describe a novel and efficient photoredox
catalytic
Cα radical addition/defluoroalkylation coupling reaction
between α-trifluoromethyl alkenes and N-trifluoroethyl
hydroxylamine. A series of gem-difluoroallylated
α-trifluoromethylamines were synthesized by the Cα radical addition enabled by a 1,2-H shift of the in situ-generated N-trifluoroethyl radical. Notably, this protocol is distinguished
by its mild conditions, easy operation, and excellent functional group
tolerability.