Variance explained by polygenic risk scores.

Dennison, Charlotte A.; Legge, Sophie E.; Bracher-Smith, Matthew; Menzies, Georgina; Escott-Price, Valentina; Smith, Daniel J.; Doherty, Aiden R.; Owen, Michael J.; O’Donovan, Michael C.; Walters, James T. R.

doi:10.1371/journal.pone.0249189.s003

pone.0249189.s003.pdf (157.42 kB)

Variance explained by polygenic risk scores.

journal contribution

posted on 2021-03-26, 17:37 authored by Charlotte A. Dennison, Sophie E. Legge, Matthew Bracher-Smith, Georgina Menzies, Valentina Escott-Price, Daniel J. Smith, Aiden R. Doherty, Michael J. Owen, Michael C. O’Donovan, James T. R. Walters

Proportion of variance (R²) explained by each polygenic score threshold, relative to a baseline model including only covariates, for (A) overall activity, and (B) specific types of activity. Asterisks indicate significant association (p<0.05) between PRS and level of activity.

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