pgen.1009571.s002.pdf (296.82 kB)
Using SWAM to impute expression and conduct TWAS.
journal contribution
posted on 2022-01-31, 18:36 authored by Andrew E. Liu, Hyun Min KangThe first panel shows how SWAM can be used to impute expression levels via prediXcan, while the second panel shows the required inputs to conduct TWAS via metaXcan.
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unravel regulatory impactssingle reference cohortlarge eqtl studyeffective sample sizedepression susceptibility genescombines arbitrary numberregulatory variants identifiedimpute expression levelstraining imputation modelscombined 49 tissueexpression data acrossintegrating multiple tissuestested imputation accuracyimputation accuracy giventranscriptome imputation modelsleverage multiple tissuesmultiple tissuestissue expressionlevel datagenetic variantsgene expressioncannot leveragetranscriptome imputationimputation methodtissue typetarget tissuespecific tissuestraightforward approachshared eqtlsresults capitalizeproposed methodpowerful methodoptimal wayoften imputedmodel trainedlinearly optimizelevel statisticslevel genotypesexternal resourcesexisting jointalso extend
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