Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of immune and central nervous system cell types. Despite extensive investigation into the aetiology of MS, the underlying cause/s remain elusive and consequently, faithful in vitro or in vivo preclinical models of MS do not exist. Advances in human stem cell technologies have enabled the generation of induced pluripotent stem cells (iPSCs) from people with MS. This review summarises the discoveries made using iPSCs derived from people with MS and explores their current and potential application/s in MS research.
Funding
Medical Research Future Fund
History
Publication title
Multiple Sclerosis and Related Disorders
Volume
63
Pagination
103839
ISSN
2211-0348
Department/School
Menzies Institute for Medical Research
Publisher
Elsevier BV
Place of publication
Netherlands
Rights statement
Copyright 2022 The Author(s) Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Repository Status
Open
Socio-economic Objectives
Expanding knowledge in the biomedical and clinical sciences