Unprecedented Diterpenoids as a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller
journal contributionposted on 2013-01-18, 00:00 authored by Lin-Fu Liang, Tibor Kurtán, Attila Mándi, Li-Gong Yao, Jia Li, Wen Zhang, Yue-Wei Guo
Methyl sarcotroates A and B (3 and 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3′,4′]cyclobuta[1′,2′:4,5]cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 3 was determined by TDDFT ECD calculations. Compound 4 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), being similar to that of positive control oleanolic acid.
Read the peer-reviewed publication
Sarcophyton trocheliophorumUnprecedented Diterpenoidscompound 3configurationHainantetradecahydrocyclopentaprotein tyrosine phosphatase 1 Bditerpenoidspectroscopic analysisPTP 1Bbiogenetic precursorCoral Sarcophyton trocheliophorum MarenzellerMethyl sarcotroatesPTP 1B Inhibitorcontrol oleanolic acidCompound 4TDDFT ECD calculationssarcophytonolide