pone.0290371.s009.pdf (4.73 MB)
Underlying blots from the time of the original experiments for Figs 1–4, 6–7, and S1–S4.
journal contribution
posted on 2024-01-17, 18:52 authored by Su Hyoun Lee, Kwang Chul ChungHistory
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upstream regulatory mechanismpathological neurodegenerative eventsaccumulating evidence indicatestoxic protein aggregatesprotein 7 (<div >< pvarious target proteinsusp7 may playpromotes substrate ubiquitinationprogressive neuronal losscommon neurodegenerative diseasemitigate er stressfbxo7 er stressvarious typestarget substratesprotein synthesisadaptor proteinpark15 fbxo7 er ),usp7 actstaken togethersubstantia nigrasubcellular organellesremoving ubiquitinpositively regulatingparkinson ’novel regulatorinduced cytotoxicityfunctional relationshipfbxo7 functionsendoplasmic reticulumdopaminergic neuronsdeubiquitinating enzymealthough fbxo7>) gene
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