pone.0258876.s004.pdf (402.21 kB)
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journal contribution
posted on 2022-01-05, 18:27 authored by Carlos M. Roggero, Victoria Esser, Lingling Duan, Allyson M. Rice, Shihong Ma, Ganesh V. Raj, Michael K. Rosen, Zhi-Ping Liu, Josep Rizo(PDF)
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using nmr spectroscopymolecular mechanisms underlyingidentify weak interactionshistone lysine demethylasesdesign effective therapiescentral kdm4a regionliquid phase separationkdm4a catalytic domainresults lead uslonger polyq sequencesalso contains lowdecrease transcriptional activitytranscriptional activitycomplexity sequencescentral rolealso showundergo liquidterminal domaindependent liquidbinding domainxlink ">requires androgenprostate cancerpolyq repeatmuscular atrophylarge nindependent activationdependent selfcontaining punctacells treatedandrogen receptor
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