pmed.1003910.s004.docx (20.02 kB)
Unadjusted associations of stroke onset time (4-hour intervals) with admission NIHSS score, neurological deterioration, and 3-month functional outcome after stratification with stroke subtypes.
journal contribution
posted on 2022-02-04, 18:35 authored by Wi-Sun Ryu, Keun-Sik Hong, Sang-Wuk Jeong, Jung E. Park, Beom Joon Kim, Joon-Tae Kim, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Man Seok Park, Kang-Ho Choi, Juneyoung Lee, Jeffrey L. Saver, Eng H. Lo, Hee-Joon Bae, Dong-Eog KimNIHSS, National Institutes of Health Stroke Scale.
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study limitations includeprestroke statin useprestroke antiplatelet useimportant additional variableearly neurological deteriorationadjusted odds ratioadjusted incidence 14461 consecutive patientshealth stroke scalemonth functional outcomelogistic regression modelscovariates including ageactive cell death7 %) patientsischemic stroke progressioninitial stroke severityterm functional outcomefavorable functional outcomexlink "> nightassessed circadian effectsstroke onset timesadmission nihss scoreadmission ), endprestroke mrs scorepresenting nihss scorestroke onset time2 versus 3term outcomefavorable outcomepresenting severitystroke onsetonset strokeprevious strokerodent modelsmean ageend ),effects orderedcircadian timeacute progressionactive phase5 %)versus nightonset strokesworse 3used mixedtreatment trialssleep disorderssd 13reperfusion agentspatient worknational institutesmonotonic gradientmay 2011lower likelihoodjuly 2020infarct growthincluded 17inactive phasehour intervalshospital arrivalfrequent endfindings suggestexperience endend occurredatrial fibrillation98 ];8 %,3 months2 groups
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