ja6b05390_si_001.pdf (1.72 MB)
Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy
journal contribution
posted on 2016-10-27, 15:24 authored by Ling Huang, Zhanjun Li, Yang Zhao, Yuanwei Zhang, Shuang Wu, Jianzhang Zhao, Gang HanTissue
penetration depth is a major challenge in practical photodynamic
therapy (PDT). A biocompatible and highly effective near infrared
(NIR)-light-absorbing carbazole-substituted BODIPY (Car-BDP) molecule is reported as a class of imaging-guidable deep-tissue
activatable photosensitizers for PDT. Car-BDP possesses
an intense, broad NIR absorption band (600–800 nm) with a remarkably
high singlet oxygen quantum yield (ΦΔ = 67%).
After being encapsulated with biodegradable PLA–PEG-FA polymers, Car-BDP can form uniform and small organic nanoparticles that
are water-soluble and tumor-targetable. Rather than using laser light,
such nanoparticles offer an unprecedented deep-tissue, tumor targeting
photodynamic therapeutic effect by using an exceptionally low-power-density
and cost-effective lamp light (12 mW cm–2). In addition,
these nanoparticles can be simultaneously traced in vivo due to their
excellent NIR fluorescence. This study signals a major step forward
in photodynamic therapy by developing a new class of NIR-absorbing
biocompatible organic nanoparticles for effective targeting and treatment
of deep-tissue tumors. This work also provides a potential new platform
for precise tumor-targeting theranostics and novel opportunities for
future affordable clinical cancer treatment.