ol1c01599_si_001.pdf (5.55 MB)
UV-Light-Induced N‑Acylation of Amines with α‑Diketones
journal contribution
posted on 2021-06-28, 19:15 authored by Zhihui Xu, Tianbao Yang, Niu Tang, Yifeng Ou, Shuang-Feng Yin, Nobuaki Kambe, Renhua QiuHerein, we develop a mild method
for N-acylation
of primary and secondary amines with α-diketones induced by
ultraviolet (UV) light. Forty-six examples with various functional
groups are explored at room temperature with irradiation by three
26 W UV lamps (350–380 nm). The yield reaches 97%. The gram
scale experiment product yield is 76%. Moreover, this system can be
applied to the synthesis of several amino acid derivatives. Mechanistic
studies show that benzoin is generated in situ from
benzil under UV irradiation.
