posted on 2019-12-02, 19:24authored byShui Yu, Yuan-Xing Zhu, Cheng Peng, Jiyang Li
Two new sterol derivatives, namely ergosterimide B (1) and demethylincisterol A5 (2), along with eleven known metabolites (3–13), were isolated from the rice fermentation culture of Aspergillus tubingensis YP-2. The chemical structures were elucidated by detailed NMR and MS spectroscopic data and by comparison with reported data. Newly isolated compound 2 and known compound 3 were evaluated for their cytotoxicities against the A549 and HepG2 cell lines. Compound 2 showed weak activities with IC50 values of 11.05 and 19.15 μM, respectively, while 3 exhibited cytotoxicities with IC50 values of 5.34 and 12.03 μM, respectively, against the tested cell lines.
Funding
This work was supported by the National Science and Technology Major Project [grant number 2009ZX09301–011] and National Science and Technology Major Project for New Drug Research and Development of MOST (2019ZX09735002-005).