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Two new compounds from biotransformation of glycyrrhetinic acid

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posted on 2024-02-02, 06:21 authored by Zehao Xie, Xinxin Gu, Aman Dekebo, Shaozhong Wei, Xuebo Hu

Glycyrrhetinic acid may undergo biotransformation to obtain derivatives with stronger pharmacological activity and fewer side effects. This study used 19 fungi to biotransform glycyrrhetinic acid and yielded two compounds namely bicyclo(14.15.27)glycyrrhetinic acid (1) and 2-ene-glycyrrhetinic acid (2) from the glycyrrhetinic acid metabolites of two fungi, Botrytis cinerea B05.10 ATCC 11542 and Aspergillus ochraceopetaliformis ATCC 12066. Compound 1 inhibited HMEC-1 cell proliferation in a concentration-dependent manner (IC50=239.1 µ M), but showed no significant cytotoxicity to A549 cells.

Funding

This work was funded by Hubei Province Administration of Traditional Chinese Medicine (No. ZY2023Z005 to SW). It is also supported by the Key R&D Program of Hubei Province for International Cooperation (No. 2022EHB047 to XH), Shennongjia Academy of Forestry, Hubei, China (No. SAF202102 to XH), Hubei Technology Innovation Center for Agricultural Sciences – ‘2020 key technology research and demonstration project of safe and efficient production of genuine medicinal materials’ (No. 2020-620-000-002-04 to XH).

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    Natural Product Research

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    Keywords

    Glycyrrhetinic acidbicyclo(14.15.27)glycyrrhetinic2-ene-glycyrrhetinic acidbiotransformationfungicytotoxicity

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    CC BY 4.0

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