posted on 2024-03-04, 19:30authored byPatrick S. Fier, Suhong Kim
We
report the design and development of a transition-metal-free
cross-coupling reaction of phenols and primary amines using a simple
and readily available multifunctional reagent. The reactions work
by induced proximity and electronic activation of both the nucleophile
and the electrophile for net dehydrative C–N coupling reactions.
Notably, the reactions do not involve the use of a transition metal
for C–N bond formation, preactivation of the phenol electrophile,
or exclusion of air or moisture. The mild conditions tolerate a broad
range of functional groups and allow for this to be applied to the
late-stage functionalization of complex substrates with a wide scope
of coupling partners.