posted on 2024-02-20, 18:05authored byZonghao Liu, Weikun Li, Xin Tan, Yueru Huang, Yinghua Tao, Ning Yang, Renqiang Yuan, Ling Liu, Liqin Ge
Improved
techniques for the administration of chemotherapeutic
drugs are required to enhance tumor therapy efficacy and reduce the
side effects of chemotherapy due to insufficient targeting and limited
intratumoral drug release. Controlled drug delivery systems combined
with thermotherapy are expected to play an important role in personalized
tumor therapy. Herein, a novel microwave-responsive transformable
magnetic liquid-metal (MLM) nanoplatform is designed for effective
endosomal escape that facilitates intracellular drug delivery and
enhanced anticancer therapy. The MLM nanoplatform exhibits a sensitive
magnetic resonance imaging function for imaging-guided therapy and
brilliant synergistic effects of chemotherapy with microwave thermal
therapy to kill tumor cells. Once endocytosed by targeted tumor cells,
the deep penetration of microwave energy can be absorbed by the MLM
nanoplatform to convert heat and reactive oxygen species, which induces
the shape transformation from nanospheres to large rods, resulting
in the physical disruption of the endosomal membrane for intracellular
drug release. Furthermore, the MLM nanoplatform synergistic therapy
could activate immunomodulatory effects by M1 macrophage polarization
and T cell infiltration, thus inhibiting tumor growth and lung metastasis.
This work based on microwave-driven transformable magnetic liquid-metal
nanoplatform provides novel ways to precisely control drug delivery
and high-efficiency cancer therapy.