TiO2/Polystyrene Nanocomposite Antibacterial
Material as a Hemoperfusion Adsorbent for Efficient Bilirubin Removal
and Prevention of Bacterial Infection
posted on 2024-02-28, 06:45authored byYunzheng Du, Mengya Chen, Biao Wang, Yamin Chai, Lichun Wang, Nan Li, Yanjia Zhang, Zhuang Liu, Chen Guo, Xinbang Jiang, Boya Ma, Zimeng Wang, Ziying Tian, Lailiang Ou
The use of hemoperfusion adsorbents for the removal of
bilirubin
in patients with liver failure has become a critical treatment. However,
the insufficient clearance of bilirubin and the possibility of bacterial
infection during hemoperfusion limit the application. In this work,
we designed a novel antibacterial bilirubin adsorbent (PSVT) through
the suspension polymerization reaction between double-bond functionalized
TiO2 nanoparticles and styrene. PSVT showed an excellent
bilirubin adsorption ability and antibacterial performance, ensuring
efficient clearance of bilirubin in liver failure patients during
hemoperfusion and preventing bacterial infection. The experimental
results indicated that TiO2 was uniformly dispersed in
the microspheres, which improved the mesoporous structure and increased
the specific surface area. Composite adsorbent PSVT showed an exceptional
bilirubin adsorption capacity, with the maximum adsorption capacity
reaching 24.3 mg/g. In addition, the introduction of TiO2 endowed PSVT with excellent antibacterial ability; the ultimate
antibacterial rates against Escherichia coli and Staphylococcus aureus reached
97.31 and 96.47%, respectively. In summary, PSVT served as a novel
antibacterial bilirubin adsorbent with excellent bilirubin clearance
capacity and antibacterial performance, providing excellent application
prospects for treating liver failure patients.