figshare
Browse
pone.0287206.s001.docx (1005.06 kB)

This file contains supplementary figures.

Download (1005.06 kB)
journal contribution
posted on 2024-01-05, 18:32 authored by Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo

These are the fully activated IV curve of S428P (S1 Fig), and P632L channels (S2 Fig), Calcium transients in normal hiPSC-CMs and hiPSC-CMs cells transfected with the P632L mutation (S3 Fig), response of rabbit Purkinje model to elevated level of sodium-calcium exchanger current following IKr blockade (S4 Fig), and IKs response following IKr blockade at 1Hz pacing (S5 Fig).

(DOCX)

History

Usage metrics

    PLOS ONE

    Categories

    Keywords

    long qt syndromeexperimental findings suggestcell derived cardiomyocytesamino acid changeheterozygous missense mutationherg current compareddiv >< pherg current blockades428p ), respectivelypurkinje cells exhibithek cells producedgo related geneherg currentherg ),partial blockadewild typeventricular myocytestransiently transfectedposition 428outer loopold infantold girlkcnh2 human etherhigher susceptibilityheterologous expressiongenetic screeningfirst mutationcomputer simulationsarrhythmogenic substratearrhythmogenic potentialsaction potentials>, resulting

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC