posted on 2021-07-28, 21:45authored byDerek B. Brown, Ayman D. Allian, Ying Chen
Thermal
hazard screening of a reaction mixture that involves the
use of propargyl alcohol as the reactant/solvent along with potassium
hydroxide as catalyst resulted in catastrophic thermal decomposition
that ruptured an accelerating rate calorimeter (ARC) test cell. Due
to this critical hazard, scale-up of the chemistry was not advisible.
In order to enable scale-up, further investigations into solvent and
base combinations were carried out. New optimum conditions enabled
the synthesis of the desired product in a safe manner. The main purpose
of this manuscript is to alert the scientific community to the thermal
hazards of this compound.