The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
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journal contribution
posted on 2024-03-12, 13:38authored byKathleen M. Gillespie, Steven C. Bain, Anthony H. Barnett, Polly J. Bingley, Michael ChristieMichael Christie, Geoffrey V. Gill, Edwin A. M. Gale
The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0·003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.