pone.0289183.s002.docx (13.64 kB)
The results of CRISPR/Cas9n mediated genomic insertion of the RGD peptide into C. novyi candidates A-E and controls.
journal contribution
posted on 2023-11-14, 18:29 authored by Kaitlin M. Dailey, James M. Small, Jessica E. Pullan, Seth Winfree, Krysten E. Vance, Megan Orr, Sanku Mallik, Kenneth W. Bayles, Michael A. Hollingsworth, Amanda E. Brooks(summarized from previously published work ref 20).
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suppressed immune systemspore coat proteinouter spore coatnecrotic — impedingintravenous injection sporesintegrin commonly overexpressedepithelial tissue surroundingdemonstrated selective efficacyaccomplish intravenous delivery>- non toxicstudy characterizes crisprclostridium novyi >- nt couldtumor targeting peptidenovyi >- ntnovyi -c typically hypoxictumor microenvironmenttumor localizationsystemic toxicitysolid tumorssolid tumorsingle dosergd peptidequickly clearedpromoter regionnt indicatesnatural bindingincreased capacityexpressed withineasily mitigatedcurrent therapeutics
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