pone.0298788.s002.docx (16.6 kB)
The missense mutations of five cell lines from cell model passports and DepMap.
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posted on 2024-02-23, 18:44 authored by Kittisak Taoma, Marasri Ruengjitchatchawalya, Monrudee Liangruksa, Teeraphan LaomettachitThe missense mutations of five cell lines from cell model passports and DepMap.
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line specific mutationsidentify distinct patternshighest single agenthighest pearson ’great balance amongfive different modesmodels reproduced celldiv >< pobserved synergistic effectsclustered drug pairsbreast cancer treatmentssynergistic effectsdrug treatmentsdrug pairsbreast cancersynergistic inhibitionsynergistic activationvast numbersilico signaling pathwaysshown potentialresponse behaviorspss provides directionprotein activitiesmechanistic understandingmechanisms underlyingintegrating informationgroups basedgene expressionexperimental datadrug combinationscorrelation coefficientcommon typesclassification metricschallenging dueboolean modelingapproach offers64 ).), determining
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