pgen.1011159.s009.pdf (222.49 kB)
The effect of TRPS1 depletion on ER target gene transcription is consistent across three independent clones.
journal contribution
posted on 2024-02-20, 18:35 authored by Thomas G. Scott, Kizhakke Mattada Sathyan, Daniel Gioeli, Michael J. GuertinFold changes in normalized PRO signal across three independent clones for ER target genes that are (A) activated or (B) repressed upon TRPS1 depletion, as defined in Fig 5A.
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inducible degron tagcommon genetic variantsbreast cancer riskfamily transcription factorer redistribution leadshigh trps1 activityrelated gene setsdiv >< ptrps1 regulates transcriptioner target genesrepressing transcriptiontrps1 modulatestrps1 primary trps1taken togetherrepressive gataregulated genesprimary effectsparticularly sensitiveinducing degradationgenomic distributiongenes relatedestrogen signalingdirect targetsdata suggestcalculated usingacutely deplete80 percent
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