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The association between gestational week of maternal intrahepatic cholestasis diagnosis and any offspring neurodevelopmental conditions, among the offspring exposed to maternal intrahepatic cholestasis (N = 10,378), separated by full-cohort analysis and full-sibling analysis.
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posted on 2024-01-16, 18:31 authored by Shuyun Chen, Viktor H. Ahlqvist, Hugo Sjöqvist, Olof Stephansson, Cecilia Magnusson, Christina Dalman, Håkan Karlsson, Brian K. Lee, Renee M. GardnerThe association between gestational week of maternal intrahepatic cholestasis diagnosis and any offspring neurodevelopmental conditions, among the offspring exposed to maternal intrahepatic cholestasis (N = 10,378), separated by full-cohort analysis and full-sibling analysis.
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several plausible pathwaysmissing covariate informationinterquartile range 11full siblings showeddifferent analytical approacheschild &# 8217adverse infant outcomesmaternal psychiatric historymaternal intrahepatic cholestasis24 ), 14302 ), thoughprescribed drug registernational patient register18 years followiatrogenic preterm birthadhd ), autismmaternal birth countrydetermine whether icpincluded singleton nonadopted children bornbased cohort studymaternal icp diagnosisoffspring neurodevelopmental conditionsneurodevelopmental conditionsmaternal age04 ),swedish registerinitial diagnosisbased analysesadhd medications5 yearsbirth yearbirth orderbirth monthneurodevelopmental conditiononset icpicp therapeuticsxlink ">study includedprimary limitationsoffspring diagnosesodds ratiosobservational designnordic originless precisejanuary 1987intellectual disabilityincreased riskincreased oddsincreased likelihoodhyperactivity disorderdecember 2016december 2010confidence intervalsbetter understandattention deficit856 children44 %)37 weeks20 ).05 %)
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