posted on 2021-10-25, 12:37authored byXuan Guo, Bing-ru Shao, Wen-feng Jiang, Lei Shi
A new
photocatalyst-free strategy for the cross-dehydrogenative
C–C and C–P coupling reaction has been described. This
protocol provides a concise method to synthesize various 1-substituted
tetrahydroisoquinoline (THIQ) derivatives enabled by visible-light
direct excitation of substrates without using any photocatalyst. Moreover,
a wide substrate scope demonstrated good synthetic versatility and
practicality.