The AR NTD also binds to the catalytic domains of KDM4B and KDM4C.

A. Model of how AR interacts with KDM4A. The model predicts that binding involves interactions of the AR NTD and DBD domains with the catalytic domain of KDM4A, as well as of the AR LBD with the region of KDM4A spanning residues 301–708. Intramolecular interactions between the DBD and LBD domains are postulated to hinder the DBD/KD4MA interactions. B. The diagrams show superpositions of ¹H-¹⁵N TROSY-HSQC spectra of ¹⁵N-KDM4B(1–348) (left) or ¹⁵N-KDM4C(1–350) (right) alone (black contours) or in the presence of equimolar amounts of unlabeled AR-NTD-DBD (red).

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