pntd.0009999.s013.docx (22.57 kB)
Targeted validity verification of GC-MS based metabolomics in plasma.
journal contribution
posted on 2021-11-29, 18:59 authored by Ole Lagatie, Emmanuel Njumbe Ediage, Dirk Van Roosbroeck, Stijn Van Asten, Ann Verheyen, Linda Batsa Debrah, Alex Debrah, Maurice R. Odiere, Ruben T’Kindt, Emmie Dumont, Koen Sandra, Lieve Dillen, Tom Verhaeghe, Rob Vreeken, Filip Cuyckens, Lieven J. StuyverPrecision obtained with different normalization strategies for the QC samples is shown.
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macrofilaricide clinical trialsinvasive tests availableepidemiological transmission studiesenable pharmacodynamic studiesdiv >< pcurrent estimates indicate17 million peopletargeted validation studyspecific lipid featuresmda efficacy surveyslymphatic filariasis cases20 individuals ).multimodal biomarker discoverydetect ongoing infectioninfected individuals (<onchocerca volvulus plasma metabolites inosineurine metabolite ccginfected casesvolvulus targeted lcspecific cutoffsassociated metabolites8 individuals68 individualsinfected worldwideefficacy biomarkerswork resultedurine metabolitesurrogate endpointssubsequent evaluationspecificity profilesriver blindnesspalpable nodulesms proceduresidentify onchocerciasisfull potentialfilarial nematodefilarial infectionendemic populationendemic controlselimination programselevated concentrationseffective monitoringcis based approach>- cinnamoylglycine7 ng2 ng1380 ng
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