pgen.1011159.s010.pdf (132.61 kB)
T47D cells do not display a cell number defect with dTAG treatment.
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posted on 2024-02-20, 18:35 authored by Thomas G. Scott, Kizhakke Mattada Sathyan, Daniel Gioeli, Michael J. GuertinCell number over time of parental T47D cells treated with dTAG or DMSO, as in Fig 6C.
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inducible degron tagcommon genetic variantsbreast cancer riskfamily transcription factorer redistribution leadshigh trps1 activityrelated gene setsdiv >< ptrps1 regulates transcriptioner target genesrepressing transcriptiontrps1 modulatestrps1 primary trps1taken togetherrepressive gataregulated genesprimary effectsparticularly sensitiveinducing degradationgenomic distributiongenes relatedestrogen signalingdirect targetsdata suggestcalculated usingacutely deplete80 percent
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