Synthesis of meta-(Indol-3-yl)phenols
from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative
Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence
posted on 2021-09-15, 14:07authored bySeung
Hwan Son, Jeong-Won Shin, Hyuck-Jae Won, Hyung-Seok Yoo, Yang Yil Cho, Soo Lim Kim, Yoon Hu Jang, Boyoung Y. Park, Nam-Jung Kim
Facile construction of a meta-(indol-3-yl)phenol
framework with a wide substrate scope (a total of 25 compounds) via
a palladium(II)-catalyzed oxidative Heck reaction and dehydrogenative
aromatization in a one-step sequence is reported. This methodology
affords a novel route for the privileged structures that are challenging
to access via a direct link between indole and phenol, in a highly
efficient and atom-economical manner.