posted on 2021-10-28, 15:08authored byBaoyu Li, Guishan Lin, Wengui Duan, Xiaoyu Wang, Bo Cen
In search of novel bioactive compounds
with excellent and broad-spectrum
antifungal activity and nanopesticides with sustained releasing property,
a series of novel myrtenal-based diacylhydrazines were designed, synthesized,
and characterized. The preliminary bioassay showed that myrtenal-based
2-picolinyl hydrazide exhibited better or comparable antifungal activity
than that of the commercial fungicides boscalid and chlorothalonil
against the tested fungi. Furthermore, myrtenal-based nanocellulose
was designed as a nanopesticide carrier and prepared from two biomass
materials, bleached bagasse pulp and turpentine oil. Drug-loading
capacities (LCs) of these carriers and sustained releasing properties
of corresponding complexes were also evaluated, and the results indicated
that the esterification reaction in the different solvents would affect
the micromorphology of carriers, which was the important influential
factor for loading or releasing drugs. To our delight, complex VIII-3 (LC = 0.32, total releasing amount/time = 99.8%/168
h) showed a macroporous framework with the drug evenly distributed
across the opening network and staged drug-releasing performance that
deserved further study as a nanopesticide.