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Synthesis of Highly Functionalized Pyridines: A Metal-Free Cascade Process

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journal contribution
posted on 2021-08-18, 16:38 authored by Kai Wei, Yu-Cui Sun, Rui Li, Jing-Feng Zhao, Wen Chen, Hongbin Zhang
Herein, we report a new process for the synthesis of highly functionalized pyridines based on a tandem Pummerer-type rearrangement, aza-Prins cyclization, and elimination-induced aromatization. This formal [5+1] cyclization provides pyridines in good yields with easily accessible starting materials. The synthetic potential of our new method is further demonstrated in the modification of the frameworks of BINOL and some natural products.