Herein, we report a new process for
the synthesis of highly functionalized
pyridines based on a tandem Pummerer-type rearrangement, aza-Prins
cyclization, and elimination-induced aromatization. This formal [5+1]
cyclization provides pyridines in good yields with easily accessible
starting materials. The synthetic potential of our new method is further
demonstrated in the modification of the frameworks of BINOL and some
natural products.