posted on 2021-08-09, 12:04authored byGuillaume Laconde, Muriel Amblard, Jean Martinez
A simple phosgene- and halogen-free
method for synthesizing α-amino
acid N-carboxyanhydrides (NCAs) is described. The
reaction between Boc-protected α-amino acids and T3P reagent
gave the corresponding NCA derivatives in good yield and purity with
no detectable epimerization. The process is safe, is easy-to-operate,
and does not require any specific installation. It generates nontoxic,
easy to remove byproducts. It can apply to the preparation of NCAs
for the on-demand on-site production of either little or large quantities.