posted on 2024-03-15, 12:08authored byChongqing Pan, Hongwei Sun, Yonglei Du, Wenbin Wang, Lingling Xu, Yu Hu, Manzhou Zhu
[2.2]Paracyclophane-fused heterocycles
represent an
important
scaffold. Traditional approaches often suffer from tedious synthetic
routes, and the development of catalytic synthesis of them remains
in its infancy. Herein, by employing highly strained aryne intermediates
as partners, we have developed a concise protocol by palladium-catalyzed
C–H activation/annulation from [2.2]paracyclophanecarboxamide
substrates. [2.2]Paracyclophane-fused quinolinone products are obtained
in good yields (up to 84%). Furthermore, the utility of the process
has been shown through the synthesis of [2.2]paracyclophane-fused
heterocyclic catalysts.