np980321c_si_001.pdf (603.82 kB)
Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides
journal contribution
posted on 1998-09-11, 00:00 authored by George G. Harrigan, Hendrik Luesch, Wesley Y. Yoshida, Richard E. Moore, Dale G. Nagle, Valerie J. Paul, Susan L. Mooberry, Thomas H. Corbett, Fred A. ValerioteA new solid tumor selective cytotoxic analogue of
dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This
metabolite has been assigned the trivial name symplostatin 1
(2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the
original source of the dolastatins, are of dietary origin.
