pcbi.1011847.s001.docx (122.82 kB)
Supporting Information.
journal contribution
posted on 2024-02-09, 18:36 authored by Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E. Via, James W. Baish, Lei Xu, Véronique Dartois, Clifton E. Barry 3rd, Rakesh K. JainS1. Species mass balance in granulomas and tumors. S2. Interstitial fluid pressure and velocity profiles. S2.1. Shell-core model of non-uniform perfusion in granulomas. S2.2. Uniform perfusion case. S2.3. Non-uniform perfusion case. S3. Comparison of interstitial perfusion for varying vascular distribution. S3.1. Predictions with the shell-core model. S3.2. Predictions with the uniform vasculature model. S3.3 Comparisons with the non-uniform vessel distribution. S4. Overcoming transport barriers. S5. Convective zone thickness. S6. Mean squared error. Abbreviations, symbols, and terminology.
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resolved experimental resultsrat carcinoma modelsexplore additional aspectsapproximate analytical solutionsinterstitial fluid velocityinterstitial fluid pressureprior experimental resultstb )– compromiselimited oxygen availabilityavascular oxygen diffusionimprove molecular transportdiv >< prabbit tb granulomasinterstitial convectionprior studiesoxygen transporttranscapillary transportsilico plasma dilutionphysiological abnormalitiesnecrosis emergemouse modelmathematical modelinitial modelgranuloma vasculaturegranuloma microenvironmentglucose concentrationdrug transportdirect resultdemonstrated mathematicallyconvective zonecellular metabolism
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