Supplementary Tables 1a-3d from A Population-Based Family Case–Control Study of Sun Exposure and Follicular Lymphoma Risk

Odutola, Michael K.; van Leeuwen, Marina T.; Bruinsma, Fiona; Turner, Jennifer; Hertzberg, Mark; Seymour, John F.; Prince, H. Miles; Trotman, Judith; Verner, Emma; Roncolato, Fernando; Opat, Stephen; Lindeman, Robert; Tiley, Campbell; Milliken, Samuel T.; Underhill, Craig R.; Benke, Geza; Giles, Graham G.; Vajdic, Claire M.

doi:10.1158/1055-9965.24967272.v1

epi-23-0578_supplementary_tables_1a-3d_suppst1-3.docx (77.39 kB)

Supplementary Tables 1a-3d from A Population-Based Family Case–Control Study of Sun Exposure and Follicular Lymphoma Risk

journal contribution

posted on 2024-01-09, 08:21 authored by Michael K. Odutola, Marina T. van Leeuwen, Fiona Bruinsma, Jennifer Turner, Mark Hertzberg, John F. Seymour, H. Miles Prince, Judith Trotman, Emma Verner, Fernando Roncolato, Stephen Opat, Robert Lindeman, Campbell Tiley, Samuel T. Milliken, Craig R. Underhill, Geza Benke, Graham G. Giles, Claire M. Vajdic

Supplementary Tables 1a-3d. Supplementary Table 1a: Bayesian information criterion for outdoor hours group-based trajectory model according to number of groups and trajectory outdoor hours. Supplementary Table 1b: Average posterior probability value and odds of correct classification for outdoor hours trajectory groups. Supplementary Table 1c: Estimated probability and the proportion of study members classified in each group according to the maximum posterior probability assignment rule. Supplementary Table 2a: Odds ratios and 95% confidence intervals for FL risk in relation to total lifetime outdoor hours during decade years among cases and related controls.Supplementary Table 2b: Odds ratios and 95% confidence intervals for FL risk in relation to outdoor hours on weekdays, weekends, and holidays at each decade year among cases and related controls. Supplementary Table 2c: Odds ratios and 95% confidence intervals for FL risk in relation to trajectories of outdoor hours across the decade years among cases and related controls. Supplementary Table 2d: Odds ratios and 95% confidence intervals for FL risk in relation to total lifetime outdoor hours during decade years among cases and unrelated controls. Supplementary Table 2e: Odds ratios and 95% confidence intervals for FL risk in relation to outdoor hours on weekdays, weekends, and holidays at each decade year among cases and unrelated controls. Supplementary Table 2f: Odds ratios and 95% confidence intervals for FL risk in relation to trajectories of outdoor hours across the decade years among cases and unrelated controls. Supplementary Table 3a: Bayesian information criterion for outdoor hours group-based trajectory model according to number of groups and trajectory outdoor hours – cases and related controls. Supplementary Table 3b: Bayesian information criterion for outdoor hours group-based trajectory model according to number of groups and trajectory outdoor hours – cases and unrelated controls. Supplementary Table 3c: Average posterior probability value and odds of correct classification for outdoor hours trajectory groups. Supplementary Table 3d: Estimated probability and the proportion of study members classified in each group according to the maximum posterior probability assignment rule.

Funding

National Health and Medical Research Council (NHMRC)

History

ARTICLE ABSTRACT

Epidemiologic evidence suggests an inverse association between sun exposure and follicular lymphoma risk. We conducted an Australian population-based family case–control study based on 666 cases and 459 controls (288 related, 171 unrelated). Participants completed a lifetime residence and work calendar and recalled outdoor hours on weekdays, weekends, and holidays in the warmer and cooler months at ages 10, 20, 30, and 40 years, and clothing types worn in the warmer months. We used a group-based trajectory modeling approach to identify outdoor hour trajectories over time and examined associations with follicular lymphoma risk using logistic regression. We observed an inverse association between follicular lymphoma risk and several measures of high lifetime sun exposure, particularly intermittent exposure (weekends, holidays). Associations included reduced risk with increasing time outdoors on holidays in the warmer months [highest category OR = 0.56; 95% confidence interval (CI), 0.42–0.76; Ptrend < 0.01], high outdoor hours on weekends in the warmer months (highest category OR = 0.71; 95% CI, 0.52–0.96), and increasing time outdoors in the warmer and cooler months combined (highest category OR = 0.66; 95% CI, 0.50–0.91; Ptrend 0.01). Risk was reduced for high outdoor hour maintainers in the warmer months across the decade years (OR = 0.71; 95% CI, 0.53–0.96). High total and intermittent sun exposure, particularly in the warmer months, may be protective against the development of follicular lymphoma. Although sun exposure is not recommended as a cancer control policy, confirming this association may provide insights regarding the future control of this intractable malignancy.