ppat.1011028.s001.pdf (121.67 kB)

Supplemental methods.

journal contribution

posted on 2022-12-30, 19:12 authored by Inge M. N. Wortel, Seonyoung Kim, Annie Y. Liu, Enid C. Ibarra, Mark J. Miller

This file contains supplemental methods and includes citations [66–71].

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versatile &# 8220 simulations provide insight listeria monocytogenes layered &# 8221 integrated quantitative parameters hunt &# 8221 following oral ingestion computer modeling approaches used complementary imaging cellular potts model intestinal goblet cells host cellular immunity preferred invasion targets invasion advantage even model consistently predicts imaging explanted mouse neutrophils &# 8220 lm &# 8212 listeria motility increases motile bacteria maintain mouse model imaging experiments target cells simulates host host phagocytes epithelial invasion xlink ">simulated data room temperature preferentially attach persistent infection pathogen dynamics neutrophils migrated mechanism mediated low temperatures lm motility lm grown lm growing lm crosses known regarding human intestine high rates first hour epithelial surface cpm predicts borne pathogen bacterial motility apical surface also examined allowing bacteria 50x faster

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