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Supplemental material. Meessen et al. Glycodeoxychol acid administration..pdf (821.38 kB)

Supplemental material. Meessen et al. Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans

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posted on 2024-05-15, 15:22 authored by Emma MeessenEmma Meessen, Soumia Majait, Umran Ay, Steven W. M. Olde Damink, Johannes A. Romijn, Jens J Holst, Bolette Hartmann, Folkert Kuipers, Max Nieuwdorp, Frank G. Schaap, Albert K. Groen, E. Marleen Kemper, Maarten R. Soeters

In this proof-of-concept study, we assessed the safety and metabolic effects of oral glycine-conjugated deoxycholic acid (GDCA) administration at 10 mg/kg/day using regular and slow-release capsules (mimicking physiological bile acid release) over 30 days in two groups of each 10 healthy lean men respectively.

Funding

ZonMW/Dutch Diabetes Fund [grant number 95105011]. Maarten R. Soeters. Emma C.E. Meessen S. Majait

\personal NWO VICI grant 2020 [09150182010020] Max Nieuwdorp

NovoNordisk Foundation grant no NNF 18CC0034900 Jens J. Holst

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    Keywords

    bile acidsglycodeoxycholic acidFarnesoid X ReceptorTakeda G protein-coupled receptor 5Glucagon-like peptide 1humansMetabolic diseases

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