pcbi.1011930.s001.pdf (1.27 MB)
Supplemental information.
journal contribution
posted on 2024-02-28, 18:38 authored by Rui Wang, Zhilin Qu, Xiaodong HuangThe supplemental information contains the following information: i) Simulation results of bidirectional regulations of Vm and submembrane Ca in different models; ii) the types of EADs; and iii) Control parameters and initial values of each model.
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two major hypothesesfour different mechanisms>< sub ><div >< palso use 5action potential modelead genesis basedca oscillations aloneaction potentialead mechanisms>well understoodventricular myocytestheoretical basesimulations provideplateau phaseoscillations causedmechanistic insightslethal arrhythmiasintracellular calciumexperimental observationseither drivenearly afterdepolarizationsead genesise .,calcium cyclingca oscillationsca cyclingbidirectionally coupledabnormal depolarizations
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