Studies Directed to the Total Synthesis
of ET 743 and Analogues Thereof:  An
Expeditious Route to the ABFGH
Subunit

Zhou, Bishan; Guo, Jinsong; Danishefsky, Samuel J.

doi:10.1021/ol016844k.s001

ol016844k_si_001.pdf (742.15 kB)

Studies Directed to the Total Synthesis of ET 743 and Analogues Thereof: An Expeditious Route to the ABFGH Subunit

journal contribution

posted on 2001-12-13, 00:00 authored by Bishan Zhou, Jinsong Guo, Samuel J. Danishefsky

In model studies directed to the total synthesis of Et743, a strategic S−C bond formation in systems 26 and 27 was demonstrated. It was further shown that Pictet−Spengler cyclization leading to spiro product 33 exhibits very high stereoselection.