posted on 2023-12-20, 16:36authored byAliakbar Mohammadlou, Ankush Chakraborty, Mitchell Maday, Xiaopeng Yin, Li Zheng, Hadi Gholami, Kumar Ashtekar, Richard Staples, William D. Wulff, Babak Borhan
This report presents a structure-guided approach for
the optimization
of VANOL-derived imidodiphosphorimidates as catalysts for the halonium-ion-induced
spiroketalization reaction. Fine tuning of the catalyst active site,
alongside enhanced acidity, was required to achieve high catalytic
activity for the spiroketalization reaction. A wide range of substrates
was well tolerated yielding halogenated spiroketals in high yields,
diastereoselectivities, and enantioselectivities.