Strongest correlations between the average expression of genes associated with keratinocyte/cornification against dedifferentiation-related genes using Montoya et al. RNA-seq dataset [28].

Leal-Calvo, Thyago; Avanzi, Charlotte; Mendes, Mayara Abud; Benjak, Andrej; Busso, Philippe; Pinheiro, Roberta Olmo; Sarno, Euzenir Nunes; Cole, Stewart Thomas; Moraes, Milton Ozório

doi:10.1371/journal.ppat.1009972.s003

ppat.1009972.s003.pdf (251.56 kB)

Strongest correlations between the average expression of genes associated with keratinocyte/cornification against dedifferentiation-related genes using Montoya et al. RNA-seq dataset [28].

journal contribution

posted on 2021-10-25, 17:33 authored by Thyago Leal-Calvo, Charlotte Avanzi, Mayara Abud Mendes, Andrej Benjak, Philippe Busso, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Stewart Thomas Cole, Milton Ozório Moraes

Scatter plots of scores (average normalized log₂ expression) calculated from genes with previously documented down-regulation in leprosy skin lesions against dedifferentiation-related genes with Montoya et al. RNA-seq dataset (GSE125943) [28]. Lines were drawn based on intercept and beta estimates from robust linear regression for all samples (black) or separately for TL (tuberculoid leprosy, blue), and LL (lepromatous leprosy, red). X-axis shows log₂ normalized expression values. Spearman’s rho are shown along with nominal 95% confidence intervals inside the plots. Most genes shown have FDR < 0.1 and rho ≤ -0.6. Related to Fig 6.

(PDF)