posted on 2023-11-20, 22:03authored byMingxiao Xie, Zicheng Wei, Zhihui Niu, Huihui Xu, Yang Guo, Jianyu Huang, Yingying Ding, Xiuling Li, Yuanda Song, Guangwu Wen, Xiaowei Li
The
bacterial microenvironment-activated nanocatalytic antibacterial
strategy has attracted extensive attention owing to the high specificity
to eliminate pathogens, which provides opportunities to solve antibiotic
resistance. However, the relatively high pH value and insufficient
endogenous H2O2 level in bacterial microenvironment
limits the efficiency of Fenton reactions induced by these nanocatalytic
agents, leading to unsatisfied antibacterial performance. Herein,
bimetallic peroxide was first reported as a high-efficiency antibacterial
nanocatalyst with high pH-activated, H2O2 self-supply
and synergistic effect-enhanced cascade Fenton chemistry. An isolated
spray vial was further developed to achieve in situ gelation at the
wound site, adapt to irregular wound surface, and maintain long-term
release of nanocatalyst. As a result, wound healing was efficiently
promoted corresponding to excellent nanocatalytic antibacterial efficacy.
Thus, our in situ sprayed nanocatalytic antibacterial gel provides
a promising paradigm for high-efficiency bacterial infection therapy.