pntd.0011455.s004.pdf (67.63 kB)
Significant DEGs between children with high S. mansoni infection intensity compared to those with low infection intensity.
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posted on 2023-11-15, 18:40 authored by Joyce Namulondo, Oscar Asanya Nyangiri, Magambo Phillip Kimuda, Peter Nambala, Jacent Nassuuna, Moses Egesa, Barbara Nerima, Savino Biryomumaisho, Claire Mack Mugasa, Immaculate Nabukenya, Drago Kato, Alison Elliott, Harry Noyes, Robert Tweyongyere, Enock Matovu, Julius MulindwaSignificant DEGs between children with high S. mansoni infection intensity compared to those with low infection intensity.
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grch38 human genomedone using deseq2div >< pcirculating anodic antigenalso observed upregulation290 million peopledata suggest expressionsignificant degs observedidentified 14 degsperipheral blood collectedmass drug treatmentalbert nile regioninfection living alonghigh infection intensitylow infection intensityvarying infection intensities20 uninfected childrenschistosoma mansoni fibrosis associated genesvarying intensitiesperipheral bloodalbert nilelow infectionschistosoma mansoni individuals livinggene expression34 highstealth infectionuninfected individualsuninfected children10 low56 degs33 degstranscriptome profilestranscriptome analysisschistosomiasis suggestsschistosomes worldwiderna extractedregulate fibrosisreads alignedpzq ),fibrosis pathologyendemic areasarea presentingadult worm
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